The molecular basis by which Cdc34 engages its E1 and the structural mechanisms by which its unique C-terminal extension functions in Cdc34 activity are unknown. ![]() Cdc34 is an E2 that plays a key role in regulating cell cycle progression and requires unique structural elements to function. ![]() Ubiquitin (Ub) signaling requires the sequential interactions and activities of three enzymes, E1, E2, and E3.
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